AUTOIMMUNE AND INFLAMMATORY DISEASES BIOMARKERS
نویسندگان
چکیده
منابع مشابه
Autoimmune and Inflammatory Diseases Biomarkers
One of the major challenges facing the healthcare industry is how to personalize, or tailor healthcare products and services to individuals' unique genetic and biomarker make-ups. Biomarkers are characteristics that can be objectively measured and evaluated. They provide information about normal or patho-physiological processes to detect or define disease progression or to predict or quantify t...
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Interleukin-1 family 7 (IL-1F7) is a novel member of IL-1F cytokines. IL-1F7 is more commonly known as IL-37. IL-37 join the α-subunit of the IL-18 receptor, or IL-18 binding protein (IL-18BP), and binding of these proteins can enhance the IL-18 suppression. IL-37 also translocates to the cell nucleus and affects gene transcription. IL-37 inhibits the phosphorylation of p38 mitogen-activated pr...
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In an ideal scenario, a biomarker would both reveal the driver of disease and identify an effective treatment. In oncology, genetic biomarkers that molecularly or clinically classify patient populations for targeted therapies, e.g., BRAF [1] and HER-2 [2], have been clinically validated and are reaching this ideal. However, biomarkers are necessarily based on the pathobiology of the underlying ...
متن کاملBiomarkers in Inflammatory Childhood Diseases
1 Centre of Molecular and Cellular Intervention, Department of Paediatric Immunology, University Medical Centre Utrecht, Lundlaan 6, 3584 EA Utrecht, The Netherlands 2 Department of Paediatric Rheumatology and Immunology, University Children’s Hospital Muenster, Muenster, Germany 3 Institute of Immunology, University Hospital Muenster, 48147 Muenster, Germany 4Department of Science, University ...
متن کاملTh17 Response and Inflammatory Autoimmune Diseases
The proinflammatory activity of T helper 17 (Th17) cells can be beneficial to the host during infection. However, uncontrolled or inappropriate Th17 activation has been linked to several autoimmune and autoinflammatory pathologies. Indeed, preclinical and clinical data show that Th17 cells are associated with several autoimmune diseases such as arthritis, multiple sclerosis, psoriasis, and lupu...
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ژورنال
عنوان ژورنال: International Journal of Biomedical and Advance Research
سال: 2012
ISSN: 2229-3809
DOI: 10.7439/ijbar.v3i4.347